Cd39 and cd73 for the therapy of hemorrhagic shock

A method for treating or reducing development of acute respiratory distress syndrome in a subject, comprising administering to the subject an amount of a CD39 mimic and/or CD73 mimic effective to treat or reduce development of acute respiratory distress syndrome;

• or
• a method of treating hemorrhagic shock or hypovolemic shock in a subject, of reducing the likelihood of multi-organ failure in a subject who has had a hemorrhagic shock or hypovolemic shock, or for ameliorating ischemia-reperfusion injury in an organ of a subject who has had a hemorrhagic shock or hypovolemic shock,
• the method comprising administering to the subject an amount of a CD39 mimic and/or CD73 mimic effective to treat hemorrhagic shock or hypovolemic shock;
• or
• a method of decreasing liver injury, or reducing an increase in lung permeability and neutrophil infiltration, associated with hypovolemic shock in a subject comprising transfusing into the subject having hypovolemic shock an amount of a CD39 mimic and/or CD73 mimic, sufficient to decrease liver injury, or sufficient to decrease an increase in lung permeability and neutrophil infiltration, associated with hypovolemic shock.