Method for evaluation of ischemic stroke effects on cognitive function of patients using brain age model

A method of predicting an effect of ischemic stroke on an individual's cognitive status, comprising:

• (1) acquiring at least one medical brain image of an individual's brain after the ischemic stroke of the individual;
• (2) processing the medical brain image to obtain at least one feature of the image;
• (3) generating a gray matter brain age (GMBA) value and/or a predicted age difference (PAD) value of the individual based on the at least one feature of the image;
• and
• (4) predicting an individual's post-stroke cognitive impairment (PSCI) future change using the GMBA value, or a combination of the predicted age difference (PAD) and a chronological age.

A method of predicting an effect of ischemic stroke on an individual's cognitive status, comprising:

• (1) acquiring T1w MRI data of an individual's brain after an ischemic stroke of the individual using T1-weighted (T1w) imaging;
• (2) processing the acquired T1w MRI data to obtain grey matter (GM) image segments;
• (3) registering the GM image segments obtained in step (2) to a standard space to obtain the deformation map of the individual's brain;
• (4) extracting a set of determinants of GM based on the deformation map in step (3);
• (5) calculating the GMBA by inputting the extracted set of determinants of GM to an established brain age model;
• (6) predicting a post-stroke CDR sum of box (CDR-SB) change of the individual based on the GMBA;
• and
• (7) outputting the post-stroke CDR-SB change in an output terminal.

A non-transitory computer readable medium storing a program causing a computer to execute a process for a method of predicting an effect of ischemic stroke on an individual's cognitive status, comprising:

• (1) acquiring at least one medical brain image of an individual's brain after the ischemic stroke of the individual;
• (2) processing the medical brain image to obtain at least one feature of the image;
• (3) generating a gray matter brain age (GMBA) value of the individual based on the at least one feature of the image;
• and
• (4) predicting an individual's post-stroke cognitive impairment (PSCI) future change using the GMBA value.

A non-transitory computer readable medium storing a program causing a computer to execute a process for a method of predicting an effect of ischemic stroke on an individual's cognitive status, comprising:

• (1) acquiring T1w MRI data of an individual's brain after an ischemic stroke of the individual using T1-weighted (T1w) imaging;
• (2) processing the acquired T1w MRI data to obtain grey matter (GM) image segments;
• (3) registering the GM image segments obtained in step (2) to a standard space to obtain the deformation map of the individual's brain;
• (4) extracting a set of determinants of GM based on the deformation map in step (3);
• (5) calculating the GMBA by inputting the extracted set of determinants of GM to an established brain age model;
• (6) predicting a post-stroke CDR sum of box (CDR-SB) change of the individual based on the GMBA;
• and
• (7) outputting the post-stroke CDR-SB change in an output terminal.