Static mixers for use with biopharmaceutical compositions and methods for using the same
AssigneeSartorius Stedim Fmt SAS
InventorsMichael Zumbrum, William Kimmick
Life of this patent
Estimating the term…
Abstract
A static mixer for use with biopharmaceutical compositions includes a shell and a core. The shell defines a flow channel therethrough. The shell is formed as a lattice structure that defines a plurality of voids in fluid communication with the flow channel. The core is disposed within the flow channel of the shell. The core is configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the flow channel. The first fluid or the second fluid is a biopharmaceutical composition.
Claims40
A static mixer for use with biopharmaceutical compositions, the static mixer comprising:
- a shell defining a flow channel therethrough, the shell formed as a lattice structure that defines a plurality of voids in fluid communication with the flow channel;
- and
- a core disposed within the flow channel of the shell, the core configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the flow channel, the first fluid or the second fluid being a biopharmaceutical composition.
A static mixer for use with biopharmaceutical compositions, the static mixer comprising:
- a shell defining a flow channel therethrough, the shell having a first end and second end opposite the first end, the first end and the second end spaced apart by a shell wall, the first end and the second end in fluid communication with each other through the flow channel, the shell wall formed as a lattice structure such that the shell wall defines a plurality of voids therethrough;
- and
- a core disposed within the shell, the core and the shell wall configured to mix a biopharmaceutical composition with another composition and prevent damage to the biopharmaceutical composition during mixing.
A method of mixing biopharmaceutical compositions, the method comprising:
- inserting a static mixer into a coupler;
- and
- flowing a first fluid and a second fluid through the static mixer such that the first fluid and the second fluid are mixed together while the shear stress experienced by the first fluid and the second fluid during mixing remains below a predetermined shear stress.
A method of manufacturing a static mixer for mixing biopharmaceutical compositions, the method comprising:
- simulating flow of a first fluid and a second fluid through a coupler including a static mixer;
- determining a topology of the static mixer to mix the first fluid and the second fluid while limiting the shear stress for the first fluid and the second fluid below a predetermined shear stress;
- and
- forming, by additive manufacturing, the static mixer with the determined topology.
A static mixer for use with biopharmaceutical compositions, the static mixer comprising:
- a core having a first end and second end opposite the first end, the core defining a first set of flow channels and second set of flow channels, the first set of flow channels extending between the first end and the second end along a longitudinal axis of the core, the second set of flow channels extending transverse to the longitudinal axis of the core, the core configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the first set of flow channels and the second set of flow channels, the first fluid or the second fluid being a biopharmaceutical composition.
Dependencies are inferred from the claim text.