System and method for identifying feature in an image of a subject

A method of registering first image data to second image data, the method comprising:

• acquiring the first image data based on at least a region of interest of a subject;
• acquiring the second image data based on a plurality of individual image projections as a plurality of input images of the region of interest of the subject;
• and
• generating a plurality of synthetic images based on the first image data to correlate to the second image data, wherein generating the plurality of synthetic images comprises:
• masking a target feature and a first set of features adjacent to the target feature;
• generating a first transformation of the target feature to a first image feature;
• masking the target feature and a second set of features adjacent to the target feature based on the generating the first transformation;
• and
• generating a second transformation of the target feature to a second image feature.

A system to register first image data to second image data, comprising:

• a processor module configured to execute instructions to:
• acquire the first image data based on at least a region of interest of a subject;
• acquire the second image data based on a plurality of individual image projections as a plurality of input images of the region of interest of the subject;
• generate a plurality of synthetic images based on the first image data to correlate to the second image data;
• generate a synthetic image of a device based on a device model;
• identify the device in the second image data based at least on the synthetic image of the device;
• and
• generate a transformation of the generated plurality of synthetic images to the second image data.