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AssigneeUniversity of Massachusetts
InventorsJae-Hyuck Shim, Guangping Gao, Aijaz Ahmad John Bhat, Jun Xie, Yeon-Suk Yang
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Aspects of the disclosure relate to compositions and methods for modulating bone growth, for example by increasing osteogenesis and/or decreasing osteoclastogenesis. The disclosure is based, in part, on recombinant adeno-associated virus (rAAV) vectors encoding microRNAs or miRNA inhibitors that inhibit endogenous miR-214-3p and/or mediate overexpression of miR-34a-5p in osteoblasts and osteoclasts. In some embodiments, compositions described by the disclosure are useful for treating certain bone diseases or disorders, such as osteoporosis.
A nucleic acid comprising a transgene encoding one or more miR-34-5p microRNAs (miRNAs) flanked by adeno-associated virus (AAV) inverted terminal repeats (ITRs).
A nucleic acid comprising a transgene encoding a miRNA inhibitor that inhibits expression of miR-214-3p in a subject flanked by adeno-associated virus (AAV) inverted terminal repeats (ITRs).
A method of inhibiting bone loss in a subject, the method comprising administering to a subject having bone loss a nucleic acid or rAAV as described in any of the preceding claims.
A method of increasing bone growth in a subject, the method comprising administering to a subject having increased bone density a nucleic acid or rAAV as described in any of the preceding claims.
A method for treating or preventing osteoporosis in a subject, the method comprising administering to a subject having, suspected of having, or at risk of having osteoporosis a nucleic acid or rAAV as described in any of the preceding claims.
Dependencies are inferred from the claim text.