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US 2026/0028600 A1Published application
Transaminase polypeptides
AssigneeCodexis, Inc.
InventorsIsh K. Dhawan, Gregory Miller, Xiyun Zhang
Life of this patent
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Abstract
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
Claims19
An engineered transaminase polypeptide, wherein said transaminase polypeptide comprises a polypeptide sequence at least 90% identical to SEQ ID NO:
- 2, and wherein the transaminase polypeptide comprises a substitution at one or more positions selected from the group consisting of X417, X317, X85, X314, X318, X320, X319, X409, X166, X434, X44, X12, and X82.
Dependencies are inferred from the claim text.