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AssigneesFibroGen, Inc., Hifibio SAS
InventorsDavid Olsen, Qian Zhang, Ling Dong, Tom Pohl, Fortunato Ferrara, Andrew Bradbury, Mitchell C. Brenner, Gail Walkinshaw
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Provided herein are affinity matured anti-galectin-9 (Gal9) antibodies. The antibodies have improved binding affinity to Gal9. Also provided herein are method of use of the affinity matured anti-Gal9 antibodies, including methods of treatment of cancer, methods of rescuing or promoting effector T cell proliferation, methods of enhancing effector T cell activity, and/or of identifying and treating cancer in a subject including the administration of the anti-Gal9 antibodies described herein. Also provided are polynucleotides encoding the heavy chain or the light chain or the antigen-binding portion thereof described herein, and vectors, especially expression vectors, including the polynucleotides described herein.
An isolated monoclonal antibody or an antigen-binding fragment thereof comprising:
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Dependencies are inferred from the claim text.