Recombinant cytokine receptors and methods of use
AssigneeSonoma Biotherapeutics, Inc.
InventorsJoshua BEILKE, James MATTHAEI, Frederic VAN GOOL, Jessica CORTEZ
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Abstract
Provided are recombinant cytokine receptors that comprise an IL-2 intracellular domain and an extracellular domain that binds to a cytokine other than IL-2. Also provided herein are Treg cell comprising recombinant cytokine receptors and methods of use.
Claims42
A regulatory T cell (Treg) comprising a recombinant cytokine receptor, wherein the recombinant cytokine receptor comprises
- an extracellular cytokine receptor domain, a transmembrane domain, and an intracellular IL-2 receptor beta chain domain, wherein the extracellular cytokine receptor domain binds to a cytokine other than IL-2.
A recombinant cytokine receptor comprising an extracellular cytokine receptor domain, a transmembrane domain, and an intracellular IL-2 receptor beta chain domain, wherein the extracellular cytokine receptor domain is able to bind to a cytokine other than IL-2.
A recombinant cytokine receptor comprising an extracellular cytokine receptor domain, a transmembrane domain, and an intracellular IL-2 receptor beta domain, wherein the extracellular cytokine receptor domain is able to bind to and is tethered to a cytokine other than IL-2.
Dependencies are inferred from the claim text.