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US 2026/0028376 A1Published application
Ch505 envelopes to engage and mature cd4 binding site neutralizing antibodies
OwnerDrew Weissman, Mohamad-Gabriel Alameh +4inventors
InventorsDrew Weissman, Mohamad-Gabriel Alameh, Barton F. Haynes, Kevin O. Saunders, David Montefiori, Kevin J. Wiehe
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Abstract
In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelopes with optimized sequences for antibody induction. In some embodiments, the invention provides mRNA sequences of said HIV-1 immunogens.
Claims32
A recombinant HIV-1 envelope polypeptide selected from the group consisting of HV1302791, HV1302934, HV1302920,
- HV1301288_G458Y_N197D, and HV1303443, wherein the polypeptide is a non-naturally occurring protomer designed to form an envelope trimer.
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Dependencies are inferred from the claim text.