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US 2026/0028356 A1Published application
1,3,4,7-tetrahydro-2h-pyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors
AssigneeAbbVie Inc.
InventorsGeorge A. Doherty, Vikram Bhat, Patrick Brady, Yujia Dai, Jianchun Gong, Andrew S. Judd, Andrew J. Souers, Yiyun Yu
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Abstract
The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.
Claims16
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein,
- L is selected from the group consisting of —NH—, —NHCH2—, and —OCH2—;
- W is selected from the group consisting of N and CH;
- A is selected from the group consisting of cyclobutyl, cyclopentyl, cyclohexyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dioxanyl, and piperidinyl;
- wherein A is optionally substituted with one or two R2 substituents and optionally substituted with one R3 substituent;
- R1 is selected from the group consisting of Cl and —NO2;
- R2 is selected from the group consisting of F, Cl, Br, I, —OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C2-C6 alkoxyalkyl, and C2-C6 alkoxyalkoxy;
- and
- R3 is selected from the group consisting of cyclobutyl, oxetanyl, and morpholinyl.
6 more elements
Dependencies are inferred from the claim text.