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US 2026/0028329 A1Published application
Jak1 selective inhibitors
AssigneeAstraZeneca AB
InventorsKARL MAGNUS NILSSON, Annika Birgitta Margareta ÅSTRAND, Anna Ingrid Kristina BERGGREN, Johan R. JOHANSSON, Matti Juhani LEPISTÖ, Sameer Pralhad KAWATKAR, Qibin SU, Jason Grant KETTLE
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Abstract
Disclosed herein are compounds of Formula (I), and pharmaceutically accepable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.
Claims21
A compound of Formula (I):
- wherein:
- R1, R3, and R4 are each individually chosen from hydrogen and methyl;
- R2 is chosen from hydrogen, methyl, and —CH2CH2OH;
- n is 1 or 2;
- R5 is chosen from methyl, ethyl, and —CH2OR8;
- R6 is chosen from methyl, chlorine, and fluorine;
- R7 is selected from methyl, ethyl, and cyclopropyl;
- and
- R8 is selected from methyl, ethyl, and benzyl;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.