cRGD -CONJUGATED IMAGING AGENT
AssigneeCuradel Surgical Innovations, Inc.
InventorJohn V. Frangioni
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Abstract
The present invention relates to an imaging agent comprising a ZW700-1c dye conjugated to a cyclic-RGD peptide targeting ligand. The conjugate of the invention has superior stability and desirable in vivo properties as compared to other zwitterionic near-infrared contrast agents. The invention also relates to a method of imaging cells of a subject using the imaging agent. In particular, the invention relates to a method of imaging or identifying cells of a subject which are or are suspected of overexpressing one or more integrins using the imaging agent. Such cells include tumors, inflammatory cells, and cells undergoing angiogenesis.
Claims14
An imaging agent dye comprising a ZW700-1c conjugated to a cyclic-RGD peptide targeting ligand.
An imaging agent comprising a conjugate having the formula:
- or a salt, solvate, or hydrate thereof.
A method of imaging cells, the method comprising:
- (a) contacting cells with an imaging agent, wherein the imaging agent is:
- wherein L is an optional linking group;
- (b) irradiating the cells at a wavelength absorbed by the imaging agent;
- (c) and detecting a signal from the compound, thereby imaging the cells.
Dependencies are inferred from the claim text.