Ultrasound mediated delivery of drugs
AssigneeExact Therapeutics AS
InventorsAndrew John Healey, Per Christian Sontum, Svein Kvale
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Abstract
The present invention relates to ultrasound (US) mediated delivery of therapeutic agents, such as the delivery of a drug, gene, nanoparticle or radioisotope, using a bi-phasic microparticle system comprising gas microbubbles, emulsion microdroplets and clusters thereof. Thus, the present invention relates to a cluster composition and a pharmaceutical composition, and their use for delivery of therapeutic agents and as a contrast agent for ultrasound imaging. It further relates to methods for delivering such therapeutic agents and to the use of said compositions.
Claims19
(canceled)
A method of treating a subject, comprising:
- administering a cluster composition to the subject, the cluster composition comprising a gaseous component and an oil component;
- applying a first application of acoustic energy comprising a frequency of about 2-10 MHz to enlarge the cluster composition;
- and
- applying a second application of acoustic energy comprising a frequency of about 200-1000 kHz to oscillate the cluster composition, the second application of acoustic energy different from the first application of acoustic energy.
Dependencies are inferred from the claim text.