Methods of Treating Glioblastoma
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsJacques Galipeau, Hsiang-Chuan Hsieh
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Abstract
In certain embodiments, this disclosure relates to conjugates including GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically, the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors including nucleic acid encoding polypeptide conjugates, and protein expression systems including these vectors such as infectious viral particles and host cells including such nucleic acids.
Claims7
A method of treating glioblastoma comprising administering an effective amount of autologous T cells comprising a vector encoding a conjugate comprising a GM-CSF polypeptide and an IL-7 polypeptide having the amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof.
A method of treating glioblastoma comprising administering into a tumor of a subject in need thereof an effective amount of a vector encoding a conjugate comprising a GM-CSF polypeptide and an IL-7 polypeptide having the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.