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US 2026/0027192 A1Published application
Combined delivery of antigens and tolerogenic signals via dual-sized hydrogel spheres and mof composites for type-1 diabetes vaccine development
AssigneeThe Hong Kong University of Science and Technology
InventorsJin Teng CHUNG, Chi Ming Laurence LAU, Ying CHAU
Life of this patent
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Abstract
It pertains to a novel platform for the sustained release of Type-1 diabetes antigens. More specifically. it provides a combination of dual sized hydrogel particles for the delivery of Type-1 diabetes antigens and multi-component adjuvants to confer immune tolerance.
Claims16
A hydrogel comprising a nanoparticle, a microparticle, at least one peptide on the surface of the nanoparticle, and at least one zwitterionic motif on the surface of the microparticle, wherein each of the nanoparticle and the microparticle comprises a polysaccharide.
Dependencies are inferred from the claim text.