Compositions and methods for treating bacterial disease
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMagdalene So, Maria A. Rendon-Espinosa
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Abstract
The present invention relates to compositions and methods for preventing and/or treating bacterial disease (e.g., disease caused by Neisseria sp. such as Neisseria gonorrhoeae or Neisseria meningitidis). In particular, the present invention provides compositions comprising an effective amount of a nucleic acid, wherein such compositions are capable of killing or inhibiting the growth of a Neisseria sp.
Claims22
A method for the inhibition of bacterial growth and/or for the killing of a target bacterium, comprising the step of adding to the target bacterium a composition comprising an effective amount of a nucleic acid comprising at least one DNA uptake sequence (DUS) and a nucleic acid encoding at least a portion of one or more Ngo DNA methyltransferases selected from the group consisting of ngoAXIV, ngoAl, and ngoAXV, thereby inhibiting bacterial growth and/or killing said bacteria.
A composition comprising a nucleic acid comprising at least one DNA uptake sequence (DUS) and a nucleic acid encoding one or more Ngo DNA methyltransferases selected from the group consisting of NgoAXIV, NgoAl, and NgoAXV, and a pharmaceutically acceptable carrier.
(canceled)
A composition comprising a nucleic acid comprising at least one DNA uptake sequence (DUS) and a nucleic acid encoding at least a portion of one or more Ngo DNA genes selected from the group consisting of tdfF, tdfH, and iga, and a pharmaceutically acceptable carrier.
22-23. (canceled)
Dependencies are inferred from the claim text.