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US 2026/0027062 A1Published application
Improved oral pharmaceutical formulations of therapeutic peptides and proteins
AssigneeCyprumed GmbH
InventorsFlorian FÖGER, Martin WERLE
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Abstract
The present invention relates to a solid oral pharmaceutical composition comprising (i) a core comprising a peptide or protein drug, and (ii) a first coating, wherein the first coating comprises a copolymer (A) in combination with a copolymer (B) and/or a copolymer (C) and/or a copolymer (D).
Claims20
A solid oral pharmaceutical composition comprising:
- (i) a core comprising a peptide or protein drug, and
- (ii) a first coating, wherein the first coating comprises
- (ii-1) a copolymer (A) in combination with
- (ii-2) a copolymer (B) and/or a copolymer (C) and/or a copolymer (D);
- wherein the copolymer (A) comprises:
- (a) 20 to 90 mol-% ethyl acrylate repeating units, and
- (b) 10 to 80 mol-% methyl methacrylate repeating units;
- wherein the copolymer (B), if present, comprises:
- (a) 25 to 75 mol-% methacrylic acid repeating units, and
- (b) 25 to 75 mol-% ethyl acrylate repeating units;
- wherein the copolymer (C), if present, comprises:
- (a) 25 to 60 mol-% methacrylic acid repeating units, and
- (b) 40 to 75 mol-% methyl methacrylate repeating units;
- wherein the copolymer (D), if present, comprises:
- (a) 5 to 20 mol-% methacrylic acid repeating units, and
- (b) 20 to 40 mol-% methyl methacrylate repeating units, and
- (c) 60 to 75 mol-% methyl acrylate repeating units.
14 more elements
Dependencies are inferred from the claim text.