Biphasic controlled-release formulation and preparation method therefor

Abstract

The present invention relates to a biphasic controlled-release preparation and preparation thereof. The biphasic controlled-release preparation can take effect quickly in vivo, quickly reach a peak value of blood drug concentration, then keep stable release, maintain stable blood drug concentration and reduce the fluctuation between wave peaks and wave valleys. The controlled-release preparation consists of three parts, namely an immediate-release layer, a tablet core layer and a blocking layer. The immediate-release layer is rapidly dissolved in vitro, and the combination of the remaining tablet core layer and the blocking layer can maintain the zero-order release in vitro.

Dependencies are inferred from the claim text.