System for predicting a prognosis of the neuropsychological and/or neuropsychiatric status in a subject

A system for predicting a prognosis of a neuropsychological and/or a neuropsychiatric status in a subject, the system comprising:

• a first device for measuring or obtaining data regarding the neuropsychiatric and/or neuropsychological status of a subject at a time T0, said data comprising information related to Minor Hallucination (MH) events, wherein said MH events comprise sense of presence and/or passage hallucinations and/or visual illusions;
• a second measuring device for measuring electrophysiological data of the subjects at a time T0, said electrophysiological data comprising frontal theta oscillatory frequency band power and/or activity;
• and
• a data analyzing device for gathering and analyzing the data regarding the neuropsychiatric and/or neuropsychological status and the electrophysiological data and comparing the data to a reference;
• wherein a report or a presence of said Minor Hallucination (MH) events, in the absence of report or presence of Visual Hallucination (VH) events, together with an enhanced frontal theta oscillatory frequency band power and/or activity only in frontal brain regions and in the absence of alterations in alpha and/or beta and/or gamma oscillatory pattern(s), is indicative of a negative prognosis of the neuropsychological and/or neuropsychiatric status in the subject.

A method for predicting a prognosis of the neuropsychological and/or neuropsychiatric status in a subject, the method comprising the steps of:

• i) obtaining data regarding the neuropsychiatric status of the subject at a time T0, said data comprising information related to Minor Hallucination (MH) events, wherein said MH events comprise sense of presence and/or passage hallucinations and/or visual illusions;
• and
• ii) obtaining electrophysiological data of the subject at the time T0 comprising frontal theta oscillatory frequency band power and/or activity,
• wherein a report or a presence of said Minor Hallucination (MH) events in the absence of report or presence of Visual Hallucination (VH) events, together with an enhanced frontal theta oscillatory frequency band power and/or activity only in frontal brain regions and in the absence of alterations in alpha and/or beta and/or gamma oscillatory pattern(s), compared to a reference, is indicative of a negative prognosis of the neuropsychological and/or neuropsychiatric status in the subject.