Stable plasmin compositions for organ preservation and reconditioning
AssigneeGrifols Worldwide Operations Limited
InventorsValery NOVOKHATNY, David ROSS
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Abstract
Disclosed herein are methods and compositions for preserving or reconditioning organs prior to transplant. The compositions of the present invention contain plasmin and/or functionally active mutants thereof formulated in a pharmaceutically acceptable organ preservation solution. The compositions are stable and non-toxic to the organ intended for transplant.
Claims44
A stable composition for organ reconditioning comprising:
- plasmin,
- a lysine mimetic, and
- a pharmaceutically acceptable organ preservation solution having a pH of about 6 to about 8,
- wherein the molar ratio of plasmin:lysine mimetic is from about 1:1 to about 1:10,000.
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Dependencies are inferred from the claim text.