Methods and systems for trans-cervical delivery of agents

A method of delivering an agent into a female body, comprising:

• inserting a delivery device into a uterine cavity with a movable sheath covering an agent delivery end of the delivery device;
• uncovering the agent delivery end of the inserted delivery device by advancing a tubular shaft of the inserted delivery device;
• positioning the uncovered agent delivery end of the inserted delivery device such that a plug of the agent delivery end is placed at a cornual region of the uterine cavity, wherein the plug comprises an inflatable balloon;
• inflating the inflatable balloon to isolate and seal the cornual region;
• and
• injecting an agent into the inserted delivery device and delivering the agent to a fallopian tube via the agent delivery end.

A device for trans-cervical delivery of agents, comprising:

• a handle including a plurality of ports;
• an obturator coupled to the handle, the obturator including a first tri-lumen extrusion forming a first flexible catheter and a second tri-lumen extrusion forming a second flexible catheter, wherein the first and second flexible catheters are in fluid communication with the plurality of ports;
• a movable insertion tube surrounding the obturator;
• and
• an agent delivery end including a distal end of the first flexible catheter and a distal end of the second flexible catheter;
• wherein the agent delivery end is configured to self-position within a uterus, and wherein each of the first flexible catheter and the second flexible catheter of the agent delivery end is configured to deliver agents independently to a fallopian tube.