A computer-implemented method of determining if a medical data sample requires referral for investigation for a disease

A computer-implemented method of ranking a plurality of medical data examples within a reference data set, the method comprising:

• receiving the reference data set;
• and
• performing pairwise comparison of each medical data example within the reference data set against every medical data example within the reference data set;
• and
• ranking the plurality of medical data examples according to a degree of severity of disease based on the pairwise comparisons.

A non-transitory computer-readable medium including instructions stored thereon that when executed by one or more processors cause the processor to:

• perform a pairwise comparison of the medical data sample against each example of medical data in a reference data set using one or more machine learning algorithms to determine a difference in severity of the medical data compared to each example medical data in the reference data set;
• and
• flag the medical data sample as requiring referral for investigation for the disease based on results of the pairwise comparisons,
• wherein the reference data set includes a plurality of medical data examples, the plurality of medical data examples ranked according to their degree of severity of disease.