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US 2026/0015653 A1Published application
Methods for increasing resolution of spatial analysis
Assignee10x Genomics, Inc.
InventorsJennifer Chew, Yifengq Yin, Layla Katiraee
Life of this patent
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Abstract
Provided herein are methods for capturing an analyte from a first region of interest of a biological sample on a substrate, where the biological sample comprises the first region of interest and a second region, and where the method includes contacting the second region with a sealant in order to create a hydrophobic seal thereby preventing an interaction between an analyte from the second region with a capture domain of a capture probe.
Claims21
-20. (canceled)
A composition comprising:
- a substrate comprising a plurality of capture probes affixed to a surface of the substrate;
- a tissue section in contact with the plurality of capture probes;
- and
- a liquid sealant applied to an area on:
- (i) the surface outside or surrounding the tissue section and/or (ii) the tissue section or a portion thereof.
2 more elements
Dependencies are inferred from the claim text.