Pi3k inhibitor, preparation method therefor, and use thereof

A compound as represented by formula I, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof, or a deuterated compound thereof:

• wherein,
• R1 is a substituent in ring A, which has m substituents;
• each R1 is independently selected from the group consisting of substituted or unsubstituted C1-C8 alkyl, C1-C8 alkoxy, halogen, cyano, nitro, hydroxy, carboxyl, —NHR15, —NHR8, —C(O)NHR8, —C(O)NHR15, substituted or unsubstituted (3-8)-membered cycloalkyl, substituted or unsubstituted (6-10)-membered aryl, substituted or unsubstituted (4-10)-membered heterocycloalkyl, substituted or unsubstituted (5-10)-membered heteroaryl;
• m is selected from the group consisting of 0, 1, 2, or 3;
• R15 is selected from the group consisting of H, substituted or unsubstituted C1-C8 alkyl, C1-C8 alkoxy, halogen, cyano, nitro, hydroxy, carboxyl, substituted or unsubstituted (3-8)-membered cycloalkyl, substituted or unsubstituted (6-10)-membered aryl, substituted or unsubstituted (4-10)-membered heterocycloalkyl, substituted or unsubstituted (5-10)-membered heteroaryl;
• Y1 and Y2 are each independently selected from the group consisting of absence, CR4R5, and NR4;
• R4 and R5 are each independently selected from the group consisting of H and C1-C8 alkyl;
• alternatively, R4 and R5, together with a carbon, form a ketone group;
• R3 is selected from the group consisting of H, (6-10)-membered aryl substituted with n R6, (5-10)-membered heteroaryl substituted with n R6, (4-10)-membered heterocycloalkyl substituted with n R6 or
• each R6 is independently selected from the group consisting of substituted or unsubstituted C1-C8 alkyl, C1-C8 alkoxy, halogen, cyano, nitro, amino, hydroxy, —C(O)OR81, —C(O)R81,
• cyanomethyl, phosphonyl, sulfonic acid group, sulfonamido, boric acid group, —NHR8 or —C(O)NHR8;
• alternatively, two R6 linked to the same atom form ═O;
• n is selected from the group consisting of 0, 1, 2, 3, or 4;
• R81 is selected from the group consisting of H, substituted or unsubstituted C1-C8 alkyl, and amino;
• R8 is selected from the group consisting of substituted or unsubstituted C1-C8 alkyl, hydroxy, and
• R7 and R9 are each independently selected from the group consisting of C1-C8 alkyl and (6-10)-membered aryl;
• X1 is selected from C or N;
• provided that X1 is C, ring A is benzene ring;
• provided that X1 is N, ring A is dihydropyridine;
• X2 is selected from C or N;
• provided that X2 is C, the bond linking X2 to O is a double bond, and the bond linking X2 to X3 is a single bond;
• provided that X2 is N, the bond linking X2 to O is a single bond, and the bond linking X2 to X3 is a double bond, with N carrying a positive charge and O carrying a negative charge;
• X3 is selected from the group consisting of N, CR10 or NR10;
• X4 is C;
• X5 is selected from the group consisting of O, N, NR10, or CR10;
• R10 is selected from the group consisting of H as well as substituted or unsubstituted C1-C8 alkyl;
• provided that X3 is selected from CR10 and X5 is O, the bond linking X3 to X4 is a double bond, the bond linking X4 to X5 is a single bond, and the bond linking X5 to C is a single bond;
• provided that X3 is selected from NR10 and X5 is N, the bond linking X3 to X4 is a single bond, the bond linking X4 to X5 is a double bond, and the bond linking X5 to C is a single bond;
• provided that X3 is selected from CR10 and X5 is selected from CR10, the bond linking X3 to X4 is a single bond, the bond linking X4 to X5 is a double bond, and the bond linking X5 to C is a single bond;
• alternatively, the bond linking X3 to X4 is a double bond, the bond linking X4 to X5 is a single bond, and the bond linking X5 to C is a double bond;
• provided that X3 is selected from CR10 and X5 is N, the bond linking X3 to X4 is a double bond, the bond linking X4 to X5 is a single bond, and the bond linking X5 to C is a double bond;
• provided that X3 is N and X5 is selected from NR10, the bond linking X3 to X4 is a double bond, the bond linking X4 to X5 is a single bond, and the bond linking X5 to C is a single bond;
• R2 is selected from the group consisting of substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted (3-8)-membered cycloalkyl, substituted or unsubstituted (6-10)-membered aryl, substituted or unsubstituted (4-10)-membered heterocycloalkyl, substituted or unsubstituted (5-10)-membered heteroaryl, —NR11R12,
• and —SR11;
• R11 and R12 are each independently selected from the group consisting of H, substituted or unsubstituted C1-C8 alkyl, and amino;
• the substituent of the alkyl is selected from the group consisting of deuterium, halogen, hydroxy, cyano, nitro, carboxyl, (4-10)-membered heterocycloalkyl, or —NR13R14;
• R13 and R14 are each independently selected from the group consisting of H and C1-C8 alkyl;
• the substituent of the cycloalkyl, aryl, heteroaryl or heterocycloalkyl is selected from the group consisting of halogen, hydroxy, amino, carboxyl, nitro, cyano, —C(O)NR16R17, —C(O)OR16, substituted or unsubstituted C1-C8 alkyl or C1-C8 alkoxy;
• R16 and R17 are each independently selected from the group consisting of H, substituted or unsubstituted C1-C8 alkyl, and hydroxy;
• The heteroatoms in the heteroaryl and heterocycloalkyl are selected from the group consisting of N, O, or S, and the number of heteroatoms is selected from the group consisting of 1, 2, or 3.