Acylsulfonamide kat6a inhibitors

A compound of Formula (J):

• or a pharmaceutically acceptable salt thereof,
• wherein
• X is O or NR4;
• ring A is a phenyl or heteroaryl;
• ring B is a phenyl or heteroaryl;
• each R1 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C2-C6 alkoxyalkyl, halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, —C(O)R1a, —C(O)OR1a, —OC(O)R1a, —C(O)N(R1a)(R1b), —N(R1a)C(O)(R1b), —OC(O)N(R1a)(R1b), —N(R1a)C(O)(OR1b), —S(O)R1a, —S(O)2R1a, —S(O)2N(R1a)(R1b), —S(O)(NH)R1a, —S(O)(NH)N(R1a)(R1b), —N(R1a)(R1b), OH, —CN, —NO2, C3-C8 cycloalkyl, (C1-C3 alkyl)(C3-C8 cycloalkyl), —O—(C3-C8 cycloalkyl), heterocycloalkyl, (C1-C3 alkyl)(heterocycloalkyl), —O-(heterocycloalkyl), C6-C10 aryl, (C1-C3 alkyl)(C6-C10 aryl), —O—(C6-C10 aryl), heteroaryl, (C1-C3 alkyl)(heteroaryl), or —O-(heteroaryl), wherein each alkyl is substituted with 0, 1, 2, 3, 4, 5, or 6 R1c, each alkoxy and alkynyl is substituted with 0, 1, 2, or 3 R1d, and each cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is substituted with 0, 1, 2, or 3 R1e;
• each R1a and R1b is independently hydrogen or C1-C6 alkyl;
• each R1c is independently C1-C6 alkoxy, halogen, C1-C6 haloalkoxy, —NR1c1R1c2 OH, or —CN;
• each R1c1 and R1c2 is independently hydrogen or C1-C6 alkyl;
• each R1d is independently deuterium, C3-C8 cycloalkyl, heterocycloalkyl, C6-C10 aryl, or heteroaryl;
• each R1e is independently C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, OH, or —CN;
• alternatively, two R1 groups on adjacent carbons together with the atoms to which they are attached combine to form a C5-C8 cycloalkyl or a heterocycloalkyl substituted with 0, 1, 2, 3, 4, 5, or 6 halogen, C1-C4 alkyl, OH or —CN;
• L is —C1-C4 alkylene-, —(C1-C4 alkylene)-O—, or —O—;
• R2 is a heteroaryl, which is substituted with 0, 1, 2, 3, or 4 R2a;
• each R2a is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C2-C6 alkoxyalkyl, halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, —C(O)R2b, —C(O)OR2b, —OC(O)R2b, —C(O)N(R2b)(R2c), —N(R2b)C(O)(R2c), —S(O)2R2b, —S(O)2N(R2b)(R2c), —N(R2b)(R2c), OH, —CN, or —NO2;
• each R2b and R2c is independently hydrogen or C1-C6 alkyl;
• each R3 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C2-C6 alkoxyalkyl, halogen, C1-C6 haloalkyl, C1-C6 haloalkoxy, —C(O)R3a, —C(O)OR3a, —OC(O)R3a, —C(O)N(R3a)(R3b), —N(R3a)C(O)(R3b), —OC(O)N(R3a)(R3b), —N(R3a)C(O)(OR3b), —S(O)R3a, —S(O)2R3a, —S(O)2N(R3a)(R3b), —S(O)(NH)R3a, —S(O)(NH)N(R3a)(R3b), —N(R3a)(R3b), OH, —CN, —NO2, C3-C8 cycloalkyl, (C1-C3 alkyl)(C3-C8 cycloalkyl), —O—(C3-C8 cycloalkyl), heterocycloalkyl, (C1-C3 alkyl)(heterocycloalkyl), —O-(heterocycloalkyl), C6-C10 aryl, (C1-C3 alkyl)(C6-C10 aryl), —O—(C6-C10 aryl), heteroaryl, (C1-C3 alkyl)(heteroaryl), or —O-(heteroaryl), wherein each alkyl is substituted with 0, 1, 2, 3, 4, 5, or 6 R3c, each alkoxy is substituted with 0, 1, 2, or 3 R3d, and each cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is substituted with 0, 1, 2, or 3 R3e;
• or,
• two R3 on the same carbon atom together represent an oxo group;
• each R3a and R3b is independently hydrogen or C1-C6 alkyl;
• each R3c is independently C1-C6 alkoxy, halogen, C1-C6 haloalkoxy, —NR3c1R3c2, OH, or —CN;
• each R3c1 and R3c2 is independently hydrogen or C1-C6 alkyl;
• each R3d is independently C3-C8 cycloalkyl, heterocycloalkyl, phenyl, or heteroaryl;
• each R3e is independently C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, or C1-C6 haloalkoxy;
• R4 is hydrogen or C1-C6 alkyl;
• subscript n is 0, 1, 2, 3, or 4;
• and
• subscript q is 0, 1, 2, 3, or 4;
• wherein
• each heterocycloalkyl is a 3- to 8-membered ring that includes 1 to 4 heteroatoms each independently N, O or S;
• and
• each heteroaryl is a 5- to 6-membered ring that includes 1 to 4 heteroatoms each independently N, O or S.