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US 2026/0014236 A1Published application
Activators of coagulation factor x and formulations thereof for treating bleeding disorders
AssigneeJiangsu Biojetay Biotechnology Co., Ltd.
InventorsZan ZHOU, Xiaomin WANG, Bingzhang WANG, Junyong LIU
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Abstract
Provided are the compositions (e.g., pharmaceutical compositions) of coagulation factor X activator (FX activator, e.g., RVV-X) comprising sucrose, histidine, polysorbate 20, and mannitol, and uses of FX activators (e.g., RVV-X) or compositions (e.g., pharmaceutical compositions) thereof for treating a bleeding disorder (e.g., hemophilia) in an individual (e.g., human).
Claims21
A pharmaceutical composition, comprising:
- i) a coagulation factor X activator (FX activator) in an amount of from about 0.1 U/mL to about 200 U/mL;
- ii) a stabilizer in an amount of from about 2 mg/ml to about 100 mg/ml;
- iii) a buffering agent in an amount of from about 0.1 mg/ml to about 50 mg/ml;
- iv) a surfactant in an amount of from about 0.001% (w/v) to about 0.1% (w/v);
- and
- v) a tonicity agent in an amount of from about 1 mg/ml to about 100 mg/ml;
- wherein the pharmaceutical composition has a pH of from about 6.0 to about 8.0.
4 more elements
2-123. (canceled)
Dependencies are inferred from the claim text.