US 2026/0009799 A1 · CA-IX TARGETING FLUORESCENT PROBES

Abstract

The present invention relates to the field of optical imaging. More particularly, it relates to fluorescent probes targeting carbonic anhydrase nine (CA-IX) comprising near-infrared (NIR) dyes of the cyanine. The invention also relates to the methods for preparing these compounds, to pharmaceutical compositions and kits incorporating them and to methods of use them as optical diagnostic agents in imaging or therapy of diseases such as solid tumors with hypoxic tissues involving cells expressing CA-IX.

Claims16

Dependent claims

A compound of formula (I), or a pharmaceutically acceptable salt thereof,

wherein
R1 is selected from a straight or branched C1-C10 alkyl substituted by a group —SO3H and a group of formula (II)
X is a straight or branched C1-C10 alkylene;
L is a bond or a linker;
each Y is independently a straight or branched C1-C10 alkyl substituted with at least two hydroxyl groups;
R3 is selected from hydrogen and a group phenyl or —O-phenyl optionally substituted with —SO3H;
n is an integer equal to 0 or 1.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/872,210Filed 26 Jul 2023

Priority

EP 22187427.428 Jul 2022

Published

8 Jan 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C09B 23/0066
Methine or polymethine dyes, e.g. cyanine dyes: the polymethine chain being part of a carbocyclic ring,
G01N 33/582
Involving labelled substances: with fluorescent label
A61K 49/0032
The fluorescent group being a small organic molecule: methine dyes, e.g. cyanine dyes
A61K 49/0052
Characterised by the carrier molecule carrying the fluorescent agent: small organic molecules

Ca-ix targeting fluorescent probes

Life of this patent

Ca-ix targeting fluorescent probes

Life of this patent

Abstract

Claims16