L-homoserine high-yield strain, construction method therefor, and use thereof

Abstract

The present disclosure provides a recombinant Escherichia coli strain modified by metabolic engineering means and a method for producing L-homoserine by using the same. The strain, designated as Escherichia coli having a strain number of 13-XA, is deposited in China General Microbiological Culture Collection Center (CGMCC) with an accession number of CGMCC No. 25099, dated Jun. 16, 2022. With respect to the chromosome DNA thereof, one or more genes associated with fatty acid metabolism are knocked out or attenuated, and/or a promoter is replaced for enhancement; one or more genes associated with the L-homoserine metabolic pathway are knocked out or attenuated, and/or one or more genes associated with the L-homoserine metabolic pathway are overexpressed or enhanced, and/or one or more genes associated with the L-homoserine metabolic pathway are mutated.

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