Compounds, pharmaceutical compositions containing them and their medical use for the treatment or prevention of vascular diseases

A compound of Chemical Formula 1 or Chemical Formula 2:

• or a pharmaceutically acceptable salt thereof,
• in the Chemical Formula 1 and 2,
• n is an integer of from 1 to 3, R1 and R2 are each independently C1-3alkyl, C1-3alkoxy-C1-3alkyl, —(CH2)1-3—C(R′)(R″)OH, —(CH2)1-3—N(R′)(R″), —(CH2)0-3-alkenyl, —(CH2)0-3-alkynyl, —(CH2)0-3—C(R′)(R″)CO2H, —(CH2)0-5-heterocycloalkyl, —(CH2)0-5-cycloalkyl, —(CH2)0-5-aryl, or —(CH2)0-5-heteroaryl, wherein the alkyl, heterocycloalkyl, cycloalkyl, aryl and heteroaryl are unsubstituted or optionally substituted with one or more substituents selected from the group consisting of C1-3alkyl, —CF3, C1-3alkoxy, —OCF3, halogen, CN, amino, —N(R′)(R″), —OH, —COOH, —COO—C1-3alkyl, and =O, wherein R′ and R″ are each independently H or C1-3alkyl,
• R3 is C1-3alkyl, —(CH2)O3-aryl, or —(CH2)0-3-heteroaryl, wherein the aryl or heteroaryl is unsubstituted or optionally substituted with one or more substituents selected from the group consisting of C1-3alkyl, —CF3, C1-3 alkoxy, —OCF3, halogen, —CN, amino, —OH, and —COOH;
• or
• R2 and R3 are linked together and fused with piperazinedione present in Chemical Formula 1 to form one of the following structures:
• wherein,
• X is S, SO2, CH2, O or NR6, wherein R6 is H or C1-3alkyl,
• R4 is H or C1-3alkyl, and
• R5 is H, C1-3alkyl, —(CH2)1-2-aryl, or —(CH2)1-2-heteroaryl.