Quinolinone amide compounds and uses thereof

A method of modulating myosin, the method comprising administering to a subject in need thereof a compound of Formula (III):

• or a salt thereof, wherein:
• X1, X2, X3, and X4 are each independently selected from C(R) and N, wherein no more than two of X1, X2, X3, and X4 are N;
• each R is independently selected from:
• hydrogen, halogen, —NO2, —CN, —N3, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —C(O)OR28, —OC(O)R28, —S(O)R28, and —S(O)2R28;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —C(O)OR28, —OC(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —S(O)R28, —S(O)2R28, —NO2, ═O, ═S, ═N(R28), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —C(O)OR28, —OC(O)R28, —S(O)R28, —S(O)2R28, —NO2, ═O, ═S, ═N(R28), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27;
• R21 is selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —C(O)OR28a, —OC(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27a;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a;
• R22 is selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28b, —SR28b, —C(O)R28b, —C(O)N(R28b)2, —N(R28b)C(O)R28b, —C(O)OR28b, —OC(O)R28b, —N(R28b)C(O)N(R28b)2, —OC(O)N(R28b)2, —N(R28b)C(O)OR28b, —S(O)R28b, —S(O)2R28b, —NO2, ═O, ═S, ═N(R28b), —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27b;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28b, —SR28b, —N(R28b)2, —C(O)R28b, —C(O)N(R28b)2, —N(R28b)C(O)R28b, —N(R28b)C(O)N(R28b)2, —OC(O)N(R28b)2, —N(R28b)C(O)OR28b, —C(O)OR28b, —OC(O)R28b, —S(O)R28b, —S(O)2R28b, —NO2, ═O, ═S, ═N(R28b), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;
• or
• R21 together with R22 form a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;
• R23 is selected from:
• hydrogen, halogen, —OR28c, —SR28c, —N(R28c)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from R27c;
• or
• R21 together with R23 form a 3- to 10-membered heterocycle, which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c;
• or
• R22 together with R23 form a 3- to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c;
• or
• R21, R22, and R23 together form a bicyclic heterocycle which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27c;
• R24 is selected from:
• hydrogen, halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27d;
• R24′ is selected from:
• hydrogen, halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27d;
• or R24 and R24′ together form a C3-10 carbocycle or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R27d;
• R25 is selected from:
• hydrogen, halogen, —OR28e, —SR28e, —N(R28e)2, —NO2, —CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27e;
• R26 is selected from:
• hydrogen, halogen, —OR28f, —SR28f, —N(R28f)2, —NO2, —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from R27f;
• each R27, R27a, R27b, R27c, R27d, R27e, and R27f is independently selected from:
• halogen, —OR28g, —SR28g, —N(R28g)2, —C(O)R28g, —C(O)N(R28g)2, —N(R28g)C(O)R28g, —N(R28g)C(O)N(R28g)2, —OC(O)N(R28g)2, —N(R28g)C(O)OR28g, —C(O)OR28g, —OC(O)R28g, —S(O)R28g, —S(O)2R28g, —NO2, ═O, ═S, ═N(R28g), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28g, —SR28g, —N(R28g)2, —C(O)R28g, —C(O)N(R28g)2, —N(R28g)C(O)R28g, —N(R28g)C(O)N(R28g)2, —OC(O)N(R28g)2, —N(R28g)C(O)OR28g, —C(O)OR28g, —OC(O)R28g, —S(O)R28g, —S(O)2R28g, —NO2, ═O, ═S, ═N(R28g), and —CN;
• and
• each R28, R28a, R28b, R28c, R28d, R28e, R28f, and R28g is independently selected from:
• hydrogen and halogen;
• C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —SO2—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl;
• provided the compound of Formula (III) is not

A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of Formula (III):

• or a salt thereof, wherein:
• X1, X2, X3, and X4 are each independently selected from C(R) and N, wherein no more than two of X1, X2, X3, and X4 are N;
• each R is independently selected from:
• hydrogen, halogen, —NO2, —CN, —N3, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —C(O)OR28, —OC(O)R28, —S(O)R28, and —S(O)2R28;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —C(O)OR28, —OC(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —S(O)R28, —S(O)2R28, —NO2, ═O, ═S, ═N(R28), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28, —SR28, —N(R28)2, —C(O)R28, —C(O)N(R28)2, —N(R28)C(O)R28, —N(R28)C(O)N(R28)2, —OC(O)N(R28)2, —N(R28)C(O)OR28, —C(O)OR28, —OC(O)R28, —S(O)R28, —S(O)2R28, —NO2, ═O, ═S, ═N(R28), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27;
• R21 is selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —C(O)OR28a, —OC(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27a;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27a;
• R22 is selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28b, —SR28b, —C(O)R28b, —C(O)N(R28b)2, —N(R28b)C(O)R28b, —C(O)OR28b, —OC(O)R28b, —N(R28b)C(O)N(R28b)2, —OC(O)N(R28b)2, —N(R28b)C(O)OR28b, —S(O)R28b, —S(O)2R28b, —NO2, ═O, ═S, ═N(R28b), —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27b;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28b, —SR28b, —N(R28b)2, —C(O)R28b, —C(O)N(R28b)2, —N(R28b)C(O)R28b, —N(R28b)C(O)N(R28b)2, —OC(O)N(R28b)2, —N(R28b)C(O)OR28b, —C(O)OR28b, —OC(O)R28b, —S(O)R28b, —S(O)2R28b, —NO2, ═O, ═S, ═N(R28b), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27b;
• or
• R21 together with R22 form a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27b;
• R23 is selected from:
• hydrogen, halogen, —OR28c, —SR28c, —N(R28c)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from R27c;
• or
• R21 together with R23 form a 3- to 10-membered heterocycle, which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27c;
• or
• R22 together with R23 form a 3- to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27c;
• or
• R21, R22, and R23 together form a bicyclic heterocycle which is optionally substituted with one or more substituents independently selected from halogen, —OR28a, —SR28a, —N(R28a)2, —C(O)R28a, —C(O)N(R28a)2, —N(R28a)C(O)R28a, —N(R28a)C(O)N(R28a)2, —OC(O)N(R28a)2, —N(R28a)C(O)OR28a, —C(O)OR28a, —OC(O)R28a, —S(O)R28a, —S(O)2R28a, —NO2, ═O, ═S, ═N(R28a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R27c;
• R24 is selected from:
• hydrogen, halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27d;
• R24′ is selected from:
• hydrogen, halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR28d, —SR28d, —N(R28d)2, —NO2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27d;
• or
• R24 and R24′ together form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R27d;
• R25 is selected from:
• hydrogen, halogen, —OR28e, —SR28e, —N(R28e)2, —NO2, —CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R27e;
• R26 is selected from:
• hydrogen, halogen, —OR28f, —SR28f, —N(R28f)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from R27f;
• each R27, R27a, R27b, R27c, R27d, R27e, and R27f is independently selected from:
• halogen, —OR28g, —SR28g, —N(R28g)2, —C(O)R28g, —C(O)N(R28g)2, —N(R28g)C(O)R28g, —N(R28g)C(O)N(R28g)2, —OC(O)N(R28g)2, —N(R28g)C(O)OR28g, —C(O)OR28g, —OC(O)R28g, —S(O)R28g, —S(O)2R28g, —NO2, ═O, ═S, ═N(R28g), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR28g, —SR28g, —N(R28g)2, —C(O)R28g, —C(O)N(R28g)2, —N(R28g)C(O)R28g, —N(R28g)C(O)N(R28g)2, —OC(O)N(R28g)2, —N(R28g)C(O)OR28g, —C(O)OR28g, —OC(O)R28g, —S(O)R28g, —S(O)2R28g, —NO2, ═O, ═S, ═N(R28g), and —CN;
• and
• each R28, R28a, R28b, R28c, R28d, R28e, R28f, and R28g is independently selected from:
• hydrogen and halogen;
• C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —SO2—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl;
• provided the compound of Formula (III) is not