Dihydromyricetin (dhm) derivative and preparation method and use thereof

A dihydromyricetin (DHM) derivative or a pharmaceutically acceptable salt thereof, wherein the DHM derivative is a compound shown in a formula I:

• wherein R1 is independently selected from C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, or H;
• L is selected from —(CR3R4)n-C(═X)—, —C(═X)—(CR3R4)n-, —(CR3R4)m-, —(CR3R4)n-C(═O)—NH—, —(CR3R4)n-NH—C(═O)—, —C(═O)—NH—(CR3R4)n-, —NH—C(═O)—(CR3R4)n-, —(CR3R4)n-C(═O)—NH—(CR3R4)n-, —(CR3R4)n-NH—C(═O)—(CR3R4)n-, or O—C(═O)—(CR3R4)n-, wherein X is selected from O, S, or NH;
• n and m are each independently selected from integers of 0 to 6;
• and
• R3 and R4 are each independently selected from H, C1-6 alkyl, a halogen, hydroxyl, —NR5R6, or —CN;
• R2 is selected from 3- to 12-membered heterocyclyl, wherein the 3- to 12-membered heterocyclyl is optionally substituted with C1-6 alkyl, a halogen, hydroxyl, —NR5R6, —CN, —SF5, or C1-6 alkoxy;
• or
• R2 is selected from —NR5R6,
• wherein R5 and R6 are each independently selected from H, C1-6 alkyl, or —C(═NH)NH2.