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US 2026/0008752 A1Published application
Polymorphic forms of florbetapir precursor av-105
AssigneeEli Lilly and Company
InventorAdrian Samuel VELLEKOOP
Life of this patent
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Abstract
New polymorphic crystal forms of the following compound are disclosed: This compound is used to make florbetapir (18F).
Claims16
A compound of the formula
- which is a crystalline form of AV-105 which is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising a peak at diffraction angle 2-theta of 20.7° and one or more peaks selected from the group consisting of 13.3° and 19.4°;
- with a tolerance for the diffraction angles of ±0.2 degrees.
A compound of the formula
- which is a crystalline form of AV-105 which is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising a peak at diffraction angle 2-theta of 20.7° and one or more peaks selected from the group consisting of 12.7°, 13.3°, 17.8°, 19.4° and 23.7°;
- with a tolerance for the diffraction angles of ±0.2 degrees.
A compound of the formula
- which is a crystalline form of AV-105 which is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising two peak at diffraction angle 2-theta, wherein the two peaks are selected from the group consisting of 9.0, 9.2, 10.3, 12.7, 13.3, 13.5, 17.8, 18.9, 19.4, 20.7, 22.7, 23.7, and 27.6;
- with a tolerance for the diffraction angles of ±0.2 degrees.
A compound of the formula
- which is a crystalline form of AV-105 and is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising a peak at a diffraction angle 2-theta of 13.3.° and at least one additional peak selected from the group consisting of 13.5°, 9.2° and 19.4°;
- with a tolerance for the diffraction angles of ±0.2 degrees.
A compound of the formula
- which is a crystalline form of AV-105 and is characterized by an X-ray powder diffraction pattern using CuKα radiation comprising peaks as depicted in FIG. 2.
Dependencies are inferred from the claim text.