Hydrolytically degradable zwitterionic polymers
OwnerAlexander K. Andrianovinventor
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Abstract
Provided are polymers with one or more domains. At least one domain of the polymer is zwitterionic. The zwitterionic domain may be a polyphosphazene having one or more HEPES-based groups. In various examples, the polymer is zwitterionic. The repeat unit in polyphosphazenes has the following general formula: where n is an integer. Each R may be the same or different. The pendant groups are also referred to herein as R and R′. At least one of the zwitterionic group may have the following structure: or a protonated or deprotonated form thereof. Also provided are methods of making and using the polymers of the present disclosure.
Claims18
A polymer comprising the following structure:
- wherein
- each R group may be the same or different,
- each R group is individually a substituted or unsubstituted aliphatic group or substituted or unsubstituted aryl group, wherein at least one R group of the polymer is a zwitterionic group or capable of being ionized such that the R group is zwitterionic, and
- n is 1 to 500,000.
Dependencies are inferred from the claim text.