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US 2026/0007701 A1Published application
Anticancer composition comprising stem cell-derived exosomes and preparation method therefor
AssigneeBrexogen Inc.
InventorsSue KIM, Ji Min KIM, Min Young JUNG
Life of this patent
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Abstract
The present invention relates to an anticancer composition comprising stem cell-derived exosomes and a preparation method therefor, the composition, according to the present invention, having an excellent anticancer effect and thus being usable as a cancer therapeutic agent independently or along with existing anticancer drugs.
Claims8
-12. (canceled)
A method for preparing a pharmaceutical composition for treating cancer, the method comprising the following steps:
- a first culturing step of culturing induced pluripotent stem cells in a medium;
- a selective culturing step of isolating SSEA-4 (−) cells among the cultured induced pluripotent stem cells and culturing same to differentiate into BxC stem cells;
- a second culturing step of culturing the BxC stem cells to differentiate into mesenchymal stem cells;
- a pretreatment step of pretreating the mesenchymal stem cells with interferon gamma (IFN-γ);
- a production step of culturing the pretreated mesenchymal stem cells to produce exosomes;
- and
- a separation step of isolating exosomes from the mesenchymal stem cells or a culture thereof.
4 more elements
A method for treating, preventing, alleviating, inhibiting, or palliating cancer, the method comprising:
- administering to a subject in need thereof a composition comprising exosomes isolated from induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs).
Dependencies are inferred from the claim text.