Nimodipine composition for injection

Abstract

A nimodipine composition, comprising nimodipine or a pharmaceutically acceptable salt of nimodipine, cyclodextrin, stabilizer 1, stabilizer 2, and no more than 1% (w/w) organic solvent in the combination. A preparation method for nimodipine for injection, wherein the nimodipine for injection is prepared from the composition and a solvent, and the solvent is selected from ethanol and/or water. The mass ratio of sulfobutyl ether-β-cyclodextrin to nimodipine in the nimodipine composition for injection of the present disclosure is smaller, which can be expected to reduce the safety hazards caused by sulfobutyl ether-β-cyclodextrin. The ethanol proportion of the nimodipine composition for injection of the present disclosure is significantly reduced compared to Nimotop, avoiding the toxicity problems caused by the use of large amounts of organic solvents and improving patient compliance.

Dependencies are inferred from the claim text.