Cereblon e3 ligase binding compound, pharmaceutical composition containing same, and production method therefor

A compound of Formula (I), Formula (II), Formula (III) or Formula (IV),

• or a pharmacologically acceptable salt thereof,
• wherein in the Formula (I), a dotted line is a single bond or a double bond, two X1 groups are independently selected from CH and CH2, or one X1 is CH2 and the other X1 is O, NH, NCH3, or S, Ring A is a saturated or partially unsaturated 3- to 8-membered ring that may include 1 to 3 atoms independently selected from nitrogen, oxygen, and sulfur atoms, and the ring may be substituted with one or more substituents independently selected from the group consisting of a fluorine atom, a methyl group, an ethyl group, and an oxo group, R3a is a hydrogen atom, a methyl group, —OH, —CH2OC(O)R′a, —CH2OP(O)OHOR′a, —CH2OP(O)R′a2, or —CH2OP(O)(OR′a)2, R′a is a C1-4 alkyl group, n is 0 or 1, when n is 0, Y1 is an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C1-10 alkylcarbonyl group, or an optionally substituted C1-10 alkoxycarbonyl group, when n is 1, Y1 is a single bond, CO, SO2, CH2CO, or a C1-4 alkylene group, and Ra is an optionally substituted 6- to 10-membered aryl group, an optionally substituted 5- to 7-membered monocyclic heteroaryl group, an optionally substituted 5- to 7-membered monocyclic heterosaturated ring group, or an optionally substituted and optionally partially saturated 8- to 10-membered bicyclic heteroaryl group,
• in Formula (II), a dotted line is a single bond or a double bond, two X2 groups are independently selected from CH and CH2, or one X2 is CH2 and the other X2 is O, NH, NCH3, or S, Z is a single bond or CH2, R2b is a hydrogen atom, a fluorine atom, or a methyl group, R3b is a hydrogen atom, a methyl group, —OH, —CH2OC(O)R′b, —CH2OP(O)OHOR′b, —CH2OP(O)R′b2, or —CH2OP(O)(OR′b)2, R′b is a C1-4 alkyl group, when Z is CH2, W is C or N, when W is N, R2b is absent, Y2 is a single bond, —CR″R″′—, —O—, —NR″—, —NR″C(O)—, —C(O)NR″—, —NR″SO2—, —SO2NR″—, —CH2NR″—, —NR″CH2—, —C(O)NR″CH2—, —CH2NR″C(O)—, —CH2N(COR″)—, —N(COR″)CH2—, —CH2N(COOR″)—, or —N(COOR″)CH2—, R″ and R″′ are each independently a hydrogen atom or an optionally substituted C1-4 alkyl group, or R″ and R″′ together form an optionally substituted saturated or partially unsaturated 3- to 8-membered ring which may include 1 to 3 atoms independently selected from nitrogen, oxygen, and sulfur atoms, Rb is an optionally substituted 6- to 10-membered aryl group provided that when W is N, a 6-membered aryl group is excluded, an optionally substituted 5- to 7-membered monocyclic heteroaryl group, an optionally substituted 5- to 7-membered monocyclic heterosaturated ring group provided that when W is N, a tetrahydrofuranyl group is excluded, an optionally substituted and optionally partially saturated 8- to 10-membered bicyclic heteroaryl group provided that when W is C,
• where the ring structures are unsubstituted or substituted with 1 to 5 arbitrary substituents are excluded, or an optionally substituted 5-4 spiro ring group which may contain 1 to 3 atoms independently selected from nitrogen, oxygen, and sulfur atoms, when Z is a single bond, W is C, Y2 is an optionally substituted 5-4 spiro ring divalent group which may contain 1 to 3 atoms independently selected from nitrogen, oxygen, and sulfur atoms, wherein the 5-4 spiro ring is bonded to W at any position of its 5-membered ring, and Re is an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkylcarbonyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted benzoyl group, an optionally substituted 6- to 10-membered aryl group, an optionally substituted 6- to 10-membered arylsulfonyl group, an optionally substituted 5- to 7-membered monocyclic heteroaryl group, an optionally substituted 5- to 7-membered monocyclic heterosaturated ring group, or an optionally substituted and optionally partially saturated 8- to 10-membered bicyclic heteroaryl group,
• in Formula (III), Y3 is a single bond or —NH—, and Rc is an optionally substituted 6- to 10-membered aryl group, an optionally substituted 5- to 7-membered monocyclic heteroaryl group, an optionally substituted 5- to 7-membered monocyclic heterosaturated ring group, or an optionally substituted and optionally partially saturated 8- to 10-membered bicyclic heteroaryl group,
• in Formula (IV), Y4 is a single bond, and Rd is an optionally substituted 6- to 10-membered aryl group, an optionally substituted 5- to 7-membered monocyclic heteroaryl group, an optionally substituted 5- to 7-membered monocyclic heterosaturated ring group, or an optionally substituted and optionally partially saturated 8- to 10-membered bicyclic heteroaryl group, and
• are excluded.