Compositions and methods for antigen-specific tolerance
AssigneesNorthwestern University, Myelin Repair Foundation, Inc.
InventorsStephen Miller, Michael A. Pleiss, Daniel R. Getts, Aaron Martin
Life of this patent
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Abstract
The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.
Claims19
A method of inducing antigen-specific tolerance in a subject suffering from or at risk of an autoimmune disease, transplant rejection, or allergy comprising:
- administering a composition to said subject,
- wherein said composition comprises apoptotic body surrogate and a plurality of immunodominant epitopes associated with one or more antigens suspected to cause said autoimmune disease, transplant rejection, or allergy, and
- wherein said composition induces tolerance of said at least one or more antigens in said subject.
2-8. (canceled)
(canceled)
17-19. (canceled)
A method of reducing a hypersensitivity response of a food allergy in a subject comprising:
- administering a composition comprising an apoptotic body surrogate and an immunodominant epitope of said food to said subject,
- wherein said composition induces tolerance of said food in said subject thereby reducing the hypersensitivity response of said food allergy in said subject.
21-64. (canceled)
66-124. (canceled)
Dependencies are inferred from the claim text.