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AssigneesThe Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, Aarhus University
InventorsEric A. Appel, Anton Smith, Henriette E. Autzen, Yifan Cheng
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Provided herein are compositions including lipids and copolymers in the form of a nanodisc assembly. The subject copolymers include monomer units of styrene and monomer units selected from acrylic acid and an acrylic acid derivative. In certain cases, the copolymer is a copolymer of styrene and acrylic acid. Also provided herein, is an aqueous solution comprising the subject composition. Also provided herein, are methods for producing a nanodisc assembly, including incubation of a lipid and a subject copolymer. Further provided herein, are methods for solubilizing a membrane protein in an aqueous solution, wherein the method includes forming a nanodisc assembly of a lipid bilayer having one or more membrane proteins embedded therein, and a subject copolymer. Also provided are methods of solubilizing a hydrophobic constituent in an aqueous solution, including forming a nanodisc assembly of a lipid, a hydrophobic constituent, and a subject copolymer.
A method of producing a nanodisc assembly, the method comprising:
A method of solubilizing a membrane protein in an aqueous solution, the method comprising forming a nanodisc assembly of:
A method of solubilizing a hydrophobic constituent in an aqueous solution, the method comprising forming a nanodisc assembly of:
Dependencies are inferred from the claim text.