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OwnerOliver THORN-SESHOLD, Viktorija GLEMBOCKYTE +2inventors
InventorsOliver THORN-SESHOLD, Viktorija GLEMBOCKYTE, Benedikt BAUMGARTNER, Alexander WIEGAND
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The present application relates to photostabilized or “self-healing” dyes that are constructed by attaching an azoaryl unit to a parent dye such that its optical properties are improved, particularly its optical properties that are most relevant in highly-demanding imaging, including instant brightness, signal stability, photon budget, and rate of detecting localisations. Therefore the compounds of the invention can be useful for high-performance imaging, e.g. delivering higher spatial and temporal resolution, within a shorter experimental acquisition time, and with more confidence, whether in oxygen-free conditions or in aerated conditions.
A compound comprising a fluorophore unit, an azoaryl unit, and optionally a tether unit, wherein the compound is a compound having a formulae (I-1) to (I-9):
A method for modifying the photophysical properties of a fluorophore, the method comprising covalently linking from one to four azoaryl units to the fluorophore, wherein the nature of the covalent linkage and/or the nature of the azoaryl species is optionally varied in order to find a fluorophore-azoaryl compound structure with an optimal set of photophysical properties.
Dependencies are inferred from the claim text.