Pod pump fluid management with end of drain and occlusion systems and methods

A peritoneal dialysis system comprising:

• a cycler including:
• a pneumatic valve manifold,
• an air pump positioned and arranged to supply positive and negative pneumatic pressure to the pneumatic valve manifold without intervening pneumatic storage,
• at least one pneumatic pressure sensor positioned and arranged to detect pneumatic pressure, and
• a control unit configured to use an output of the pneumatic pressure sensor as feedback to adjust the air pump according to a set pneumatic pressure;
• and
• a disposable set including a pod pump, a plurality of ports and a stopcock handle configured to selectively open and close one or more ports of the plurality of ports.

A peritoneal dialysis system comprising:

• a cycler including:
• a pneumatic valve manifold,
• an air pump positioned and arranged to supply positive and negative pneumatic pressure to the pneumatic valve manifold without intervening pneumatic storage,
• at least one pneumatic pressure sensor positioned and arranged to detect pneumatic pressure, and
• a control unit configured to use an output of the pneumatic pressure sensor as feedback to adjust the air pump according to a set pneumatic pressure;
• and
• a disposable set including a pod pump having a flexible sheet and a plurality of multi-function combination ports, one side of the flexible sheet positioned and arranged during operation to receive pneumatic pressure via the air pump and pneumatic valve manifold.