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US 2025/0375486 A1Published application
Regulate gut microbiota to treat neurodegenerative disorders
AssigneeCalifornia Institute of Technology
InventorsSarkis K. Mazmanian, Timothy R. Sampson
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Abstract
Disclosed herein are methods and compositions that can be used to improve motor deficits and neuroinflammation in subjects in need, for example subjects suffering from neurodegenerative disorders (e.g., Parkinson's disease). Also disclosed are methods and compositions that can be used to diagnose neurodegenerative disorders, such as Parkinson's disease.
Claims19
(canceled)
A method for improving a motor deficit in a subject having a disease, the method comprising:
- administering a composition comprising an inhibitor of a short chain fatty acid (SCFA) comprising propionate or butyrate;
- and
- increasing a level of a Parkinson's disease (PD)-protective bacteria in a gut microbiota of the subject;
- or
- decreasing a level of a PD-enhancing bacteria in a gut microbiota of the subject,
- wherein increasing the level of the PD-protective bacteria or decreasing the level of the PD-enhancing bacteria reduces neuroinflammation in the subject.
3 more elements
A method of diagnosing parkinsonism in a subject, comprising
- determining the presence and/or level of one or more PD-associated bacterial species in the subject, whereby the presence and/or abnormal level of the one or more PD-associated bacterial species indicates that the subject has a risk of developing, or is suffering from a symptom of parkinsonism.
A pharmaceutical composition, comprising
- an inhibitor of a PD-enhancing microbial metabolite, and
- one or more pharmaceutically acceptable carriers.
Dependencies are inferred from the claim text.