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US 2025/0375481 A1Published application
Methods and processes for manufacture of a topically adherent selective bactericide
AssigneeLintbells Limited
InventorsGlenn Francis Vile, Ann Kimberly Haigh
Life of this patent
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Abstract
Disclosed herein are processes for the manufacture of a new topically adherent selective bactericide and products resulting therefrom. More specifically a method for producing a complexed stable microbiome regulating protein configured for topical application and use of that product as a medicament, effective for therapeutic effect against pathogenic bacteria, but not commensal bacteria.
Claims25
A complexed protein comprising:
- a microbiome functional protein comprising lactoperoxidase, lactoferrin, lysomal alpha-mannosidase, immunoglobulin G, angiogenin, ribonuclease 4 or quiescin sulfhydryl oxidase and/or combinations thereof, complexed with a modified whey protein isolate (WPI) from milk, wherein the complexed microbiome functional protein is configured for topical application and, on application, to adhere to epithelial surfaces.
(canceled)
A method of producing a complexed stable microbiome regulating protein configured for topical application, the method comprising the steps of:
- selecting a microbiome regulating protein wherein the protein comprises:
- lactoperoxidase, lactoferrin, lysomal alpha-mannosidase, immunoglobulin G, angiogenin, ribonuclease 4, or quiescin sulfhydryl oxidase, and/or combinations thereof in a powder form;
- selecting a modified whey protein isolate (WPI) from milk in a gel form;
- solubilising the microbiome regulating protein in an aqueous salt solution, the aqueous salt solution having an ionic strength of 25-200 mM NaCl;
- blending together the solubilised microbiome regulating protein and modified WPI;
- adjusting the pH to 2.0-6.0;
- adjusting the temperature to 18-37° C.;
- and
- holding the blend at a pH of 2.0-6.0 and a temperature of 18-37° C. for at least 30 minutes.
6 more elements
Dependencies are inferred from the claim text.