Pharmaceutical composition and methods for modulating inflammation and oxidative stress
AssigneeIsm Biosciences LLC
InventorsMax Temnik, Oleksandr Balakin, Victor Gurin, Sergey Gurin
Life of this patent
Estimating the term…
Abstract
Disclosed are therapeutic compositions of matter for use in regulation of local and systemic inflammation and reduction of oxidative stress to enable discovery and development of more effective pharmaceutical agents, organic compounds, and other medicinal formulations.
Claims14
A pharmaceutical composition for modulating inflammation and oxidative stress in mammals including at least one chemical element selected from H, Li, C, B, N, O, Mg, Si, S, K, Cl, Ca, V, Cr, Fe, Ni, Cu, Zn, Sr, Mo, Se, Ge, Ga, Br, Rb, Ag, and Ba, or a combination thereof, wherein said chemical elements are altered from their natural sample state so that 1H is enriched to exceed 99.985%, 6Li is enriched to exceed 10.06%, 12C is enriched to exceed 98.93%, 10B is enriched to exceed 21.01%, 14N is enriched to exceed 99.64%, 16O is enriched to exceed 99.81%, 17O is enriched to exceed 0.01%, 24Mg is enriched to exceed 80.01%, 25Mg is enriched to exceed 10.01%, 28Si is enriched to exceed 92.51%, 29Si is enriched to exceed 5.01%, 32S is enriched to exceed 95.03%, 33S is enriched to exceed 0.91%, 39K is enriched to exceed 93.51%, 35Cl is enriched to exceed 76.01%, 40Ca is enriched to exceed 96.95%, 42Ca is enriched to exceed 0.65%, 43Ca is enriched to exceed 0.65%, 50V is enriched to exceed 0.25%, 50Cr is enriched to exceed 4.25%, 52Cr is enriched to exceed 85.01%, 54Fe is enriched to exceed 5.85%, 56Fe is enriched to exceed 91.8%, 58Ni is enriched to exceed 68.10%, 60Ni is enriched to exceed 26.51%, 61Ni is enriched to exceed 1.12%, 63Cu is enriched to exceed 69.10%, 64Zn is enriched to exceed 58.61%, 66Zn is enriched to exceed 28.10%, 84Sr is enriched to exceed 0.60%, 92Mo is enriched to exceed 15.01%, 94Mo is enriched to exceed 9.25%, 95Mo is enriched to exceed 15.95%, 96Mo is enriched to exceed 16.69%, 74Se is enriched to exceed 0.90%, 76Se is enriched to exceed 9.25%, 77Se is enriched to exceed 7.65%, 78Se is enriched to exceed 23.81%, 70Ge is enriched to exceed 20.55%, 72Ge is enriched to exceed 27.57%, 73Ge is enriched to exceed 7.77%, 69Ga is enriched to exceed 64.11%, 79Br is enriched to exceed 50.70%, 85Rb is enriched to exceed 72.20%, 107Ag is enriched to exceed 51.61%, 130Ba is enriched to exceed 0.12%, 132Ba is enriched to exceed 0.12%, 134Ba is enriched to exceed 2.42%, 135Ba is enriched to exceed 6.60%, and/or 136Ba is enriched to exceed 7.86%.
The pharmaceutical composition of claim, 1 further including at least one of an enzyme, a peptide, a protein, an oligonucleotide, a nucleotide, an antibody, or a combination thereof.
A method of modulating local and/or systemic inflammation in mammals including administering a therapeutically effective amount to a subject in need thereof of at least one isotope-specific chemical element selected from 6Li, 10B, 24Mg, 25Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 84Sr, 92Mo, 94Mo, 95Mo, 9% Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 69Ga, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and/or 136Ba present in elemental form, atomic form, colloidal substance form, in form of pharmaceutically acceptable compound, or in form of salt, or in combination of these forms, wherein 6Li is enriched to exceed 10.06%, 12C is enriched to exceed 98.93%, 10B is enriched to exceed 21.01%, 24Mg is enriched to exceed 80.01%, 25Mg is enriched to exceed 10.01%, 28Si is enriched to exceed 92.51%, 29Si is enriched to exceed 5.01%, 32S is enriched to exceed 95.03%, 33S is enriched to exceed 0.91%, 39K is enriched to exceed 93.51%, 35Cl is enriched to exceed 76.01%, 40Ca is enriched to exceed 96.95%, 42Ca is enriched to exceed 0.65%, 43Ca is enriched to exceed 0.65%, 50V is enriched to exceed 0.25%, 50Cr is enriched to exceed 4.25%, 52Cr is enriched to exceed 85.01%, 54Fe is enriched to exceed 5.85%, 56Fe is enriched to exceed 91.8%, 58Ni is enriched to exceed 68.10%, 60Ni is enriched to exceed 26.51%, 61Ni is enriched to exceed 1.12%, 63Cu is enriched to exceed 69.10%, 64Zn is enriched to exceed 58.61%, 66Zn is enriched to exceed 28.10%, 84Sr is enriched to exceed 0.60%, 92Mo is enriched to exceed 15.01%, 94Mo is enriched to exceed 9.25%, 95Mo is enriched to exceed 15.95%, 96Mo is enriched to exceed 16.69%, 74Se is enriched to exceed 0.90%, 76Se is enriched to exceed 9.25%, 77Se is enriched to exceed 7.65%, 78Se is enriched to exceed 23.81%, 70Ge is enriched to exceed 20.55%, 72Ge is enriched to exceed 27.57%, 73Ge is enriched to exceed 7.77%, 69Ga is enriched to exceed 64.11%, 79Br is enriched to exceed 50.70%, 85Rb is enriched to exceed 72.20%, 107Ag is enriched to exceed 51.61%, 130Ba is enriched to exceed 0.12%, 132Ba is enriched to exceed 0.12%, 134Ba is enriched to exceed 2.42%, 135Ba is enriched to exceed 6.60%, and/or 136Ba is enriched to exceed 7.86%.
A method of reducing oxidative stress including administering a therapeutically effective amount to a subject in need thereof of at least one isotope-specific chemical element selected from 6Li, 12C, 10B, 24Mg, 25Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 84Sr, 92Mo, 94Mo, 95Mo, 96Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 69Ga, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and/or 136Ba, present in elemental form, atomic form, colloidal substance form, in form of pharmaceutically acceptable compound, or in form of a salt, wherein 6Li is enriched to exceed 10.06%, 12C is enriched to exceed 98.93%, 10B is enriched to exceed 21.01%, 24Mg is enriched to exceed 80.01%, 25Mg is enriched to exceed 10.01%, 28Si is enriched to exceed 92.51%, 29Si is enriched to exceed 5.01%, 32S is enriched to exceed 95.03%, 33S is enriched to exceed 0.91%, 39K is enriched to exceed 93.51%, 35Cl is enriched to exceed 76.01%, 40Ca is enriched to exceed 96.95%, 42Ca is enriched to exceed 0.65%, 43Ca is enriched to exceed 0.65%, 50V is enriched to exceed 0.25%, 50Cr is enriched to exceed 4.25%, 52Cr is enriched to exceed 85.01%, 54Fe is enriched to exceed 5.85%, 56Fe is enriched to exceed 91.8%, 58Ni is enriched to exceed 68.10%, 60Ni is enriched to exceed 26.51%, 61Ni is enriched to exceed 1.12%, 63Cu is enriched to exceed 69.10%, 64Zn is enriched to exceed 58.61%, 66Zn is enriched to exceed 28.10%, 84Sr is enriched to exceed 0.60%, 92Mo is enriched to exceed 15.01%, 94Mo is enriched to exceed 9.25%, 95Mo is enriched to exceed 15.95%, 96Mo is enriched to exceed 16.69%, 74Se is enriched to exceed 0.90%, 76Se is enriched to exceed 9.25%, 77Se is enriched to exceed 7.65%, 78Se is enriched to exceed 23.81%, 70Ge is enriched to exceed 20.55%, 72Ge is enriched to exceed 27.57%, 73Ge is enriched to exceed 7.77%, 69Ga is enriched to exceed 64.11%, 79Br is enriched to exceed 50.70%, 85Rb is enriched to exceed 72.20%, 107Ag is enriched to exceed 51.61%, 130Ba is enriched to exceed 0.12%, 132Ba is enriched to exceed 0.12%, 134Ba is enriched to exceed 2.42%, 135Ba is enriched to exceed 6.60%, and/or 136Ba is enriched to exceed 7.86%.
Dependencies are inferred from the claim text.