Manipulation of eif3 to modulate repeat associated non-atg (ran) translation
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLaura Ranum, Fatma Ayhan, Tao Zu
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Abstract
Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
Claims21
1-37. (canceled)
A method of modulating repeat-associated non-ATG protein (RAN protein) translation, the method comprising contacting a cell expressing a RAN protein with an effective amount of a selective modulator of eukaryotic initiation factor 3 subunit m (eIF3m), wherein the selective modulator of eIF3m is a protein, a small molecule, or an inhibitory nucleic acid selected from the group consisting of dsRNA, siRNA, shRNA, miRNA, artificial miRNA (amiRNA), and an antisense oligonucleotide (ASO).
Dependencies are inferred from the claim text.