Stat degraders and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• each of X, Xa, Xb, and Xd is independently a covalent bond, —O—, —C(O)—, —C(S)—, —CR2—, —NR—, —S(O)—, —SO2—, —C(O)NR—, —SO2—, —SO2NR—, —P(O)OR—, —P(O)R—, —P(O)NR2—, —OCR2—, —C(O)CR2—, —C(S)CR2—, —CR2CR2—, —NRCR2—, —S(O)CR2—, —SO2CR2—, or an optionally substituted 5-membered heterocyclic ring;
• each R is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:
• two R groups on the same carbon or nitrogen are optionally taken together with their intervening atoms to form an optionally substituted 4-11 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclic or heterocyclic ring having 1-3 heteroatoms, in addition to the carbon or nitrogen from which the two R groups are attached, independently selected from nitrogen, oxygen, and sulfur;
• Xe is or
• X1 is a covalent bond or bivalent group selected from —O—, —C(O)—, —C(S)—, —CR2—, —NR—, —S(O)—, or —SO2—;
• X2 is a bivalent group selected from an optionally substituted C1-6 saturated or unsaturated alkylene or
• Ring F is phenylenyl, napthylenyl, a 5-10 membered heteroarylenyl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 4-11 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclylenyl or heterocyclylenyl with 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Q is a bivalent group selected from a covalent bond, —O—, —CR2—, —CF2—, —CFR—, —C(O)—, —OCR2—, and —C(S)—;
• R1 is RA, —CR2RA, —OR, —SR, —NR2, —CR2OR, —CR2NR2, —CR2NRC(O)R, —CR2NRC(O)NR2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, or —NRSO2R;
• each RA is independently an optionally substituted group selected from C1-6 aliphatic, phenyl, a 4-7 membered saturated or partially unsaturated carbocyclic or heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• R2 is hydrogen, halogen, —CN,
• each of Ring A and Ring B is independently a ring selected from phenyl, a 5-6 membered heteroaryl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 4-9 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclyl or heterocyclyl with 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each of Ra, Rb, Rc, Rd, Re, Re, R3 and R4 is independently hydrogen, RA, halogen, —CN, —NO2, —OR, —SR, —NR2, —SiR3, —SO2R, —SO2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)NROR, —CR2NRC(O)R, —CR2NRC(O)NR2, —OC(O)R, —OC(O)NR2, —P(O)R2, —P(O)(OR)2, —P(O)(OR)NR2, —P(O)(NR2)2, —OP(O)R2, —OP(O)(OR)2, —OP(O)(OR)NR2, —OP(O)(NR2)2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —NP(O)R2, —NRP(O)(OR)2, —NRP(O)(OR)NR2, —NRP(O)(NR2)2, or —NRSO2R;
• L is a covalent bond or a bivalent, saturated or partially unsaturated, straight or branched C1-20 hydrocarbon chain, wherein 0-6 methylene units of L are independently replaced by -Cy-, —O—, —NR—, —CRF—, —CF2—, —C(O)—, —S—, —S(O)—, —S(O)2—, —SiR2—, —Si(OH)R—, —Si(OH)2—, —P(O)OR—, —P(O)R—, or —P(O)NR2—,
• each -Cy- is independently an optionally substituted bivalent ring selected from phenylenyl, an 8-10 membered bicyclic arylenyl, a 4-7 membered saturated or partially unsaturated carbocyclylenyl, a 4-11 membered saturated or partially unsaturated spiro carbocyclylenyl, an 8-10 membered bicyclic saturated or partially unsaturated carbocyclylenyl, a 4-7 membered saturated or partially unsaturated heterocyclylenyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 4-11 membered saturated or partially unsaturated spiro heterocyclylenyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, an 8-10 membered bicyclic saturated or partially unsaturated heterocyclylenyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 5-6 membered heteroarylenyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic heteroarylenyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of L1 and L2 is independently a covalent bond or a bivalent, saturated or partially unsaturated, straight or branched C1-6 hydrocarbon chain, wherein 0-3 methylene units of L1 or L2 are independently replaced by —O—, —NR—, —CR2—, —CRF—, —CF2—, —C(O)—, —S—, —S(O)—, or —S(O)2—;
• Ring C is a bivalent ring selected from phenylenyl, naphthylenyl, a 5-10 membered heteroarylenyl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-11 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclylenyl or heterocyclylenyl with 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• Ring D is a bivalent ring selected a 5-14 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclyl or heterocyclyl with 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Ring E is a bivalent ring selected from phenylenyl, a 4-7 membered saturated or partially unsaturated carbocyclylenyl or heterocyclylenyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroarylenyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• La is a covalent bond or a bivalent, saturated or partially unsaturated, straight or branched C1-20 hydrocarbon chain, wherein 0-6 methylene units of L are independently replaced by -Cy-, —O—, —NR—, —S—, —P(O)(OR)—, —P(O)(R)-, —P(O)(N(R)2)—, —OC(O)—, —C(O)O—, —C(O)—, —S(O)—, —S(O)2—, —NRS(O)2—, —S(O)2NR—, —NRC(O)—, —C(O)NR—, —OC(O)NR—, —NRC(O)O—;
• Ra is hydrogen, —CN, —CHF2, —CF3, —OR, —SR, —NR2, —N+R3, —SO2R, —SO2NR2, —S(O)R, —C(O)R, —CO2R, —C(O)NR2, —P(O)R2, —P(O)(OR)2, —P(O)(OR)NR2, —P(O)(NR2)2, or
• Ring G is a ring selected from phenyl, 5-6 membered heteroaryl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 4-9 membered saturated or partially unsaturated monocyclic, bicyclic, or bridged bicyclic carbocyclyl or heterocyclyl with 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Rf is hydrogen, RA, halogen, —OR, —SR, —NR2, —SO2R, —SO2NR2, —S(O)R, —C(O)R, —CO2R, —C(O)NR2, —OC(O)R, —OC(O)NR2, —P(O)R2, —P(O)(OR)2, —P(O)(OR)NR2, —P(O)(NR2)2, —OP(O)R2, —OP(O)(OR)2, —OP(O)(OR)NR2, —OP(O)(NR2)2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —NP(O)R2, —NRP(O)(OR)2, —NRP(O)(OR)NR2, —NRP(O)(NR2)2, —C(O)P(O)R2, —C(O)P(O)(OR)2, —C(O)P(O)(OR)NR2, —C(O)P(O)(NR2)2, or —NRSO2;
• b, c, d, e, f, m, n is independently 0, 1, 2, 3, or 4;
• and
• n is 0 or 1.