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US 2025/0375452 A1Published application
Sotorasib dosing regimen
AssigneeAmgen Inc.
InventorsHaby HENARY, Gataree NGARMCHAMNANRITH, Joseph PARK, Sandeep DUTTA, Gregory FRIBERG, Brett E. HOUK, Omar MATHER
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Abstract
Provided herein are methods of treating a cancer comprising a KRAS G12C mutation in a patient with active brain metastases, comprising administering sotorasib to the patient in amount effective to treat the cancer.
Claims20
A method of treating a cancer having a KRAS G12C mutation in a human patient with active brain metastases, the method comprising administering to the human patient a therapeutically effective amount sotorasib, wherein the cancer having a KRAS G12C mutation is non-small cell lung cancer or colorectal cancer.
Dependencies are inferred from the claim text.