Small molecules and methods for inducing cardiomyocyte proliferation
OwnerJeffrey Saucerman, David L. Brautigan +2inventors
InventorsJeffrey Saucerman, David L. Brautigan, Laura Woo, Kaitlyn Wintruba
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Abstract
Methods for inducing proliferation of cardiomyocytes in vitro and in vivo are disclosed.
Claims19
A method for inducing proliferation of a cardiomyocyte culture, the method comprising contacting the cardiomyocyte culture with a therapeutic agent selected from:
A method for inducing expression of at least one of VEGFR2 (KDR) and ErbB2 expression in a cell, the method comprising contacting the cell with
A method for treating heart damage in a subject in need thereof, the method comprising administering to the subject an effective amount of a therapeutic agent selected from:
- or a pharmaceutically acceptable salt thereof.
A method for treating a subject in need thereof, the method comprising administering to the subject an effective amount of a therapeutic agent selected from:
- or a pharmaceutically acceptable salt thereof,
- wherein the subject is genetically predisposed to a heart defect or a heart condition.
Dependencies are inferred from the claim text.