US 2025/0375431 A1 · METHODS OF TREATING IDIOPATHIC PULMONARY FIBROSIS WITH DEUPIRFENIDONE

Methods of treating idiopathic pulmonary fibrosis with deupirfenidone

AssigneePureTech LYT 100, Inc.

InventorsMichael C. Chen, Eric Elenko, Heather A. Paden, Christopher C. Korth, Paul Andrew Ford, Julie S. Krop, Camilla S. Graham, Liza C. Micioni, Simon John Hatch, Varun Garg, Yanqiong Zhang, Carol Ann Satler, David Andrew Golod

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Abstract

Disclosed herein is a method of treating Idiopathic Pulmonary Fibrosis (IPF). The method includes administering to a subject in need thereof the deuterium-enriched pirfenidone LYT-100 at a total daily dose from about 1650 mg to about 2500 mg.

Claims7

Dependent claims

A method of treating Idiopathic Pulmonary Fibrosis (IPF), the method comprising orally administering to a subject in need thereof a total daily dose of 250-2500 mg of a deuterium-enriched pirfenidone having the structure:

Dependencies are inferred from the claim text.

Facts

Application

19/299,954Filed 14 Aug 2025

Priority

14 Sep 2018

Published

11 Dec 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/4412
Non condensed pyridines; Hydrogenated derivatives thereof: having oxo groups directly attached to the heterocyclic ring
A61K 31/4418
Non condensed pyridines; Hydrogenated derivatives thereof: having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
A61P 11/00
Drugs for disorders of the respiratory system
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

Family

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From the US filing history. Foreign family members aren’t listed.