Method of inhibiting lipase activity in aging
AssigneeThe Regents of the University of California
InventorsGeert W. Schmid-Schoenbein, Frank A. DeLano
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Abstract
Provided herein are methods of general biological aging in a subject, including, but not limited to specific presentations of biological aging such as mild cognitive impairment, dementia, unstable blood pressure, collagen degradation, insulin-receptor cleavage, type 2 diabetes, kidney, lung, or intestine degradation which include administering the subject a therapeutically effective amount of a lipase inhibitor.
Claims21
-63. (canceled)
A method of reversing accumulation of a lipase in an organ of a subject, comprising:
- selecting a subject having or at risk of accumulation of a lipase in the organ;
- and
- administering a therapeutically effective amount of a lipase inhibitor to the subject, thereby reversing accumulation of the lipase in the organ of the subject.
A method of treating type 2 diabetes in a subject, comprising:
- administering a therapeutically effective amount of a lipase inhibitor to the subject, thereby reducing a cleavage of one or more insulin receptors by a lipase in an organ of the subject.
A pharmaceutical composition for the treatment of aging or age-related conditions in a subject, the pharmaceutical composition comprising a lipase inhibitor.
Dependencies are inferred from the claim text.