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US 2025/0375400 A1Published application
Prophylactic skin treatment for radiation therapy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDerrick C. WAN, Michael T. LONGAKER, Geoffrey C. GURTNER
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Abstract
Methods of reducing skin fibrosis by prophylactically treating skin prior to radiation therapy arc described herein. The methods include applying an effective amount of DFO to skin that may be subjected to radiation, e.g., before treatment for cancer at a treatment site. The DFO may be administered transdermally.
Claims10
A method of decreasing radiation induced fibrosis, the method comprising:
- administering an effective amount of deferoxamine (DFO) transdermally to a region of skin of a subject at a treatment site for a first period of time of 3 days to 21 days prior to a radiation treatment;
- administering radiation to the region of skin during a second period of time of 5 days to 70 days, beginning after the first period of time;
- and
- administering an effective amount of DFO to the region of skin during a third period of time of 2 weeks to 8 weeks subsequent to the radiation administration and beginning after the second period of time.
1 more element
Dependencies are inferred from the claim text.